Discovery of a retigabine derivative that inhibits KCNQ2 potassium channels
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چکیده
منابع مشابه
Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels.
Retigabine [N-(2-amino-4-[fluorobenzylamino]-phenyl) carbamic acid; D-23129] is a novel anticonvulsant, unrelated to currently available antiepileptic agents, with activity in a broad range of seizure models. In the present study, we sought to determine whether retigabine could enhance current through M-like currents in PC12 cells and KCNQ2/Q3 K(+) channels expressed in Chinese hamster ovary ce...
متن کاملModulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine.
Retigabine is a novel anticonvulsant with an unknown mechanism of action. It has recently been reported that retigabine modulates a potassium channel current in nerve growth factor-differentiated PC12 cells (), however, to date the molecular correlate of this current has not been identified. In the present study we have examined the effects of retigabine on recombinant human KCNQ2 and KCNQ3 pot...
متن کاملACCELERATED COMMUNICATION Modulation of KCNQ2/3 Potassium Channels by the Novel Anticonvulsant Retigabine
Retigabine is a novel anticonvulsant with an unknown mechanism of action. It has recently been reported that retigabine modulates a potassium channel current in nerve growth factordifferentiated PC12 cells (Rundfeldt, 1999), however, to date the molecular correlate of this current has not been identified. In the present study we have examined the effects of retigabine on recombinant human KCNQ2...
متن کاملCalmodulin is an auxiliary subunit of KCNQ2/3 potassium channels.
Calmodulin (CaM) was identified as a KCNQ2 and KCNQ3 potassium channel-binding protein, using a yeast two-hybrid screen. CaM is tethered constitutively to the channel, in the absence or presence of Ca2+, in transfected cells and also coimmunoprecipitates with KCNQ2/3 from mouse brain. The structural elements critical for CaM binding to KCNQ2 lie in two conserved motifs in the proximal half of t...
متن کاملModulation of Potassium Channels Inhibits Bunyavirus Infection.
Bunyaviruses are considered to be emerging pathogens facilitated by the segmented nature of their genome that allows reassortment between different species to generate novel viruses with altered pathogenicity. Bunyaviruses are transmitted via a diverse range of arthropod vectors, as well as rodents, and have established a global disease range with massive importance in healthcare, animal welfar...
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ژورنال
عنوان ژورنال: Acta Pharmacologica Sinica
سال: 2013
ISSN: 1671-4083,1745-7254
DOI: 10.1038/aps.2013.79